A TPC with Tiple-GEM Gas Amplification and TimePix Readout We report on measurements with a GEM based TPC and the TimePix CMOS ASIC as charge collecting anode. Tests with a small prototype having 6 mm drift space were performed in a 5 GeV electron beam at DESY. A Si-strip-hodoscope installed in the beam also recorded the electron track position. Different GEM orientations and geometries were tested. It is shown that the point resolution for short drift distances is better than 20 micrometer. The achieved time resolution is better than 10 ns at 100 MHz clock frequency. Furthermore, experimental studies with an enlarged pixel size are addressed. To study the performance for longer drift distances a chamber with 26 cm drift length is operated in Bonn. Data with cosmic muons and in the ELSA test beam have been recorded. The spatial resolution and cluster proberties are studied in dependence on the drift distance.